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KMID : 0616120110420020110
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 2 p.110 ~ p.116
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Constituents of Flowers of Carthamus tinctorius L. and Their Antioxidant Activity
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Choi Hyun-Gyu
Kang Yan-Fu
Park Sung-Hee
Son Ae-Ryang
Na Min-Kyun
Lee Seung-Ho
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Abstract
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As part of our ongoing study focused on the discovery of antioxidants from natural products by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, methanol extract of flowers of Carthamus tinctorius L. was found to show potent antioxidant activity. Activity-guided fractionation of the methanol extract lead to the isolation of twenty compounds including two flavonol glycosides, quercertin-3-O--D-glucopyranoside (12) and kaempferol-3-O--L-rhamnopyranosyl--D-glucopyranoside (18), two flavanone glycosides, (2S)-4’,5,6,7-tetrahydroxyflavanone 6-O--D-glucopyranoside (15) and (2R)-5,7,8’,4-tetrahydroxyflavanone 8-O--D-glucopyranoside (16), and two acetylenic glycosides, 8Z-decaene-4,6-diyne-1-O--D-glucopyranoside (13) and 4,6-decadiyne-1-O--D-glucopyranoside (14). Their chemical structures were identified by using spectroscopic analysis. Among them, compounds 12-18 were tested in DPPH assay. Compounds 13-16 were first reported to their antioxidant activity. Quercertin-3-O--D-glucopyranoside (12) showed the most potent inhibitory effect on DPPH with value of 56.7 .
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KEYWORD
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Carthamus tinctorius, DPPH, Quercertin-3-O--D-glucopyranoside, Acetylenic glycoside
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